The bureau said that most of the deaths were caused by mountain torrents, landslides and avalanches triggered by rainstorms.
The bureau said local authorities are carrying out rescue work and handing out disaster relief goods, including providing quilts, rice and oil to those made homeless.
The provincial observatory said more heavy downpours were likely to hit parts of Guizhou from Saturday to Monday.
Authorities are evacuating hundreds of residents away from the areas prone to geological disasters.
Meanwhile, rainstorms have also wreaked havoc in east China’s Anhui Province and the central province of Hunan.
The Anhui provincial fire department said Saturday a part of the urban area of Anqing city was flooded on Friday.
Firefighters and police had to use life rafts to rescue some 300 stranded residents.
The Hunan Provincial Headquarters of Flood Control and Drought Relief said 317,300 people in the province have been affected by rainstorms over the past several days.
A total of 880 have been related to safe places. Rainstorms also damaged crops and irrigation facilities in the province.