Entertainment superstars including Beyonce and George Clooney will headline a telethon to raise money for victims of massive storm Harvey, organizers announced Tuesday.

The one-hour September 12 special — to be broadcast on all four US networks and livestreamed on social media platforms — will urge donations to aid groups working in the aftermath of the disaster.

Beyonce — a native of hard-hit Houston who has vowed a generous response — will be making her first public appearance since giving birth to twins in June.

Dubbed “Hand in Hand,” the telethon will also feature performances, appearances or taped messages by Hollywood A-listers Clooney, Matthew McConaughey, Julia Roberts, Adam Sandler and Reese Witherspoon.

Also scheduled to appear are singing great Barbra Streisand and talk-show titan Oprah Winfrey.

The special will take place in Los Angeles with stages in New York and Nashville, as well as a performance by Texas country music star George Strait as part of a charity concert in San Antonio.