The two London clubs sit first and second in the Premier League, but the Blues will arrive at the Emirates with a 10-point advantage over the Gunners.
With just six games left of the season, Chelsea look set to win their first league title since 2010, but their neighbours will be looking to create a bit of uncertainty in that outcome on Sunday, while also further cementing second spot.
Wenger is well aware that he has not managed to beat Mourinho in 12 attempts, but he does not think that fact will have any influence on the game this weekend.
“I am not a great believer in history. We have not always lost in 12 attempts and a few times have been close to beating them.
“But, having said that, the result on Sunday will be just down to the performance on the day.
“We’re on a good run and from a good run of form you get good belief. We have a strong solidarity too.
“We know we have passed many tests. We’ve beaten Manchester City away from home and we have another test on Sunday that we want to pass.
“What we require is to nullify Chelsea’s strengths. If you look at the numbers they have been very efficient on counter-attacks, very efficient on set-pieces.”
Even if Arsenal manage to claim victory on Sunday, Wenger admits it will still be difficult to catch Chelsea at the top of the table.
“Mathematically possible. But Chelsea have the championship in their hands but what we can do is get closer to them,” he said.
“We have an opportunity to do that at home and we want to take it. We want to strengthen our position in second because it’s far from being done.”