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New analysis on AstraZeneca COVID-19 vaccine shows it increases immune responses to Beta, Delta, Alpha and Gamma SARS-CoV-2 variants as a booster shot. /CFM

Capital Health

New AstraZeneca vaccine data supports its use as a booster shot

NAIROBI, Kenya Jan 14 – Positive results from a preliminary analysis of an ongoing safety and immunogenicity trial have shown that the AstraZeneca COVID-19 vaccine, when given as a booster shot increased the immune response to Beta, Delta, Alpha and Gamma SARS-CoV-2 variants.

This follows a separate analysis of samples from the trial that showed increased antibody response to the Omicron variant.

The results were observed among individuals previously vaccinated with either AstraZeneca COVID-19 vaccine or an mRNA vaccine.

A separate Phase IV trial reported in a preprint with The Lancet on Social Science Research Network (SSRN) showed that a third dose of AstraZeneca substantially increased antibody levels following a primary vaccine series with CoronaVac (Sinovac Biotech).

“AstraZeneca Covid-19 vaccine has protected hundreds of millions of people from Covid-19 around the world and these data show that it has an important role to play as a third dose booster, including when used after other vaccines,” stated the BioPharmaceuticals R&D, AstraZeneca Executive Vice President Sir Mene Pangalos.

The data adds to the growing body of evidence supporting AstraZeneca as a third dose booster irrespective of the primary vaccination schedules tested.

“Given the ongoing urgency of the pandemic and AstraZeneca Covid-19 vaccine’s increased immune response to the Omicron variant, we will continue to progress regulatory submissions around the world for its use as a third dose booster,” said Pangalos

“The latest AstraZeneca Covid-19 vaccine data is of particular importance considering the spread of the Omicron variant. This is good news for Sub-Saharan Africa, where over 70 million doses of the AstraZeneca Covid-19 vaccine have been supplied, and where countries are striving to attain their vaccination targets and some are beginning to roll out booster programmes,” AstraZeneca Africa Country President Barbara Nel stated.

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The D7220C00001 safety and immunogenicity trial showed that AstraZeneca Covid-19 vaccine continued to be generally well tolerated

Further analyses from the trial are expected in the first half of 2022.

Previous studies done in the United Kingdom support AstraZeneca as a third dose booster as part of a homologous or heterologous schedule.

In a sub-analysis from the COV001 and COV002 trials, a third dose of AstraZeneca COVID-19 vaccine given at least six months after a second dose significantly boosted antibody levels and maintained T cell response.

It also resulted in higher neutralising activity against the Alpha, Beta, and Delta variants, compared with a two-dose regimen.

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