An official programme from the organizers of the summit, bringing together investors from across the globe, show that the US president will deliver his speech at 10.25 am, and later visit the Power Africa Innovation at the UN compound.
He will then cross over to the US Embassy to meet officials there before heading to the US Embassy memorial park in the city centre.
Motorists have been warned to keep off Limuru Road, Forest Road through to Moi Avenue where the US presidential motorcade will pass enroute to the 1998 bomb blast memorial park.
President Obama will later on Saturday afternoon head to State House for a ceremonial welcome and talks with his host President Uhuru Kenyatta ahead of a state dinner.
President Obama arrived in the country on Friday night for his historic visit to Kenya, amid tight security at the Jomo Kenyatta International Airport.
He later on Friday night had a re-union dinner with close members of his Kenyan family.
The private dinner was held at a five star hotel in Nairobi attended by his only surviving grandmother Mama Sarah and step sister Dr Auma Obama who stole the show at the airport where she hugged him heartily.
Photographs released during the dinner shows Obama seated between Mama Sarah and Auma with whom he chatted freely as they had dinner.
Dr Auma later travelled with him on the Beast from the airport to the hotel where they had dinner after a heartily hug during introductions done by President Uhuru Kenyatta.
Due to the tight schedule of the US President in Nairobi motorists have been urged to strictly follow directions given by the police because of the massive road closures.
Roads from Waiyaki Way all through to Westlands to Gigiri will remain closed for The Beast and as well as other dignitaries attending the summit, as well as President Kenyatta who co-hosting it with the US president.
The Central Business District was a ghost town on Saturday as most Nairobi residents opted to avoid the inconveniences caused by the tight security accorded to President Obama.
The paramilitary General Service Unit (GSU) were patrolling city streets and directing motorists at key junctions.