The bus was bound for Mombasa while the truck was heading towards Nairobi when they collided between Masimba and Kiboko, about 30 kilometers from Makindu Town.
Briefing the reporters in the area, Makindu Divisional Police boss Sarah Duncan said the Akamba bus driver survived the accident and told police that the truck had veered onto the Mombasa bound lane
The driver is said to have seen the when it was too late to steer the bus from the path of the oncoming lorry and the impact ripped off an entire side of the bus.
The police boss said five people who include one child were injured and rushed to the Makindu District Hospital.
Meanwhile, the truck driver and his loader have fled the scene as police have cordoned off the area following spillage of paraffin.
The festive season is usually marred by a series of fatal road accidents as people travel up country for the celebrations.
Last week, the Traffic Police Department pledged to prevent road carnage during this festive season, launching a road safety campaign. Unlike in the past when traffic crackdowns were seen as the solution, the department has now changed tack and partnered with various organizations to sensitize motorists and pedestrians on road safety.
Within the city, the police have mounted road cameras mounted to nail rogue drivers. They also plan to re-introduce alcoblow to discourage drunken driving.