Two-drug regimen shows promise against pancreatic cancer


drug for pancreatic cancer

A combination of two chemotherapy drugs has shown promising results in fighting pancreatic cancer, significantly improving five-year survival rates, according to a European study presented Friday.

The trial showed that patients who take the oral drug capecitabine in addition to treatment with the commonly-used intravenous drug gemcitabine after surgical removal of pancreatic cancer survived longer without significant increase in negative side effects.

It was one of the largest trials ever conducted in pancreatic cancer, involving 732 patients.

The study was presented at the American Society of Clinical Oncology’s annual meeting, the world’s largest conference on cancer, currently being held in Chicago.

“Pancreatic cancer remains one of the most hard-to-treat cancers. It is a major win to find that adding a generic chemotherapy not only improves survival for these patients, but does so with little effect on patients’ quality of life,” said Smitha Krishnamurthi of Case Western Reserve University, who was not a part of the study.

Although most people diagnosed with pancreatic cancer are not candidates for surgery, the findings show that those who can have surgery “have a fighting chance of surviving this cancer with the combination of two commonly used chemotherapies,” said John Neoptolemos, the study’s lead author of the University of Liverpool in Britain.

The study showed a five-year survival rate of 28.8 percent among the group treated with both capecitabine and gemcitabine for six months, compared with 16.3 percent for the group that received gemcitabine alone during that time.

The median overall survival rate was 28 months with the combination of drugs, compared to 25.5 months with gemcitabine alone.

“The difference in median survival may seem modest, but the improvement in long-term survival is substantial for this cancer,” Neoptolemos said in a statement.

The study’s determination that the gemcitabine-capecitabine treatment is safe allows researchers to consider what other treatments could be added effectively.

According to the World Health Organization, 338,000 people in the world were diagnosed with pancreatic cancer in 2012, with the highest number of cases in North America and Europe.

Pancreatic cancer is the fourth-leading cause of cancer death in the United States, with 41,780 deaths expected in 2016.



Agence France-Presse is a global news agency delivering fast, in-depth coverage of the events shaping our world from wars and conflicts to politics, sports, entertainment and the latest breakthroughs in health, science and technology.

  • Mazzdark

    The Government that in early years taoughjt Museveni a few lessons, dealt with Matakwei and SLDF,and are now deployed in the Somalia few dare to tread….you HOPE that Government is afraid of you….WAKE UP, MRC!!!

  • Paul

    Pure rubbish. How can government fear a few MRC ? do they know what happened to SLDF etc? Stop cheating yourselves guys NO one can fear you lol! If governement wanted to clear you off (it would be just a matter of hours)

  • Leonard

    The court ruling may just be the rope that MRC will use to hang itself. The ruling has established boundaries within which the organization can operate legally. Let them use legal political means and activism to fight for the concerns of the coastal people, as would any other grouping in this great nation. If they step outside the boundaries, then the Government shall have the grounds to swat them hard. I would suggest to its leadership that this is the time to step back and reflect, and chart a more practical way forward. In as much as the coastal region has suffered marginalization to some degree, this problem is not unique to them (as a region or people) and breaking away may not be a solution. In my opinion, the solution is to hold the national and county governments accountable to one of their their primary obligations, that of playing Robin Hood – stealing from the rich and giving the poor, not the other way round.

  • Didier

    MRC is not registered under any arm of government. What is it? The court should be clear otherwise even Mungiki and Taliban will be deemed legal.

  • MRC are awfully mistaken. First, they dont realize that they are taking their people on suicide mission. Obviously they havent reckoned with grave consequences of their adventure. Saying Pwani si Kenya is quite simple and even sweet. But beyond that? Kenyans can never be afraid of MRC at all. Soon after independence, guys from North Eastern region came up with this “si Kenya” thing. They were actually backed by a former dictatorial government in Somalia. That means they were pretty well equiped and powerful. We told those who didnt want to be Kenyans to take off. We prevailed. More recently, some fellows in Mt. Elgon came up with nearly the same “Si Kenya” madness. We went there and too prevailed. Needless to say, Mt Elgon has always sustained itself with enough food supply. Mungiki also came to scene. We told them to lay off but they became difficult. We decided to make them lay off and we prevailed. In this essentially “Kwale Si Kenya” affair, if we are not careful the world will collapse on us. Before we embark on empty talk and empty ability to stand our ground, we must first think seriously whats at stake here. National territerial integrity can not be threatened by confused people only quoting treaties entered between foreign powers in total exclusion, if not utter disregard of Kenyans themselves. A few years ago, people In Pemba and Zanzibar attempted to claim tthat they were not Tanzanians, Eventually they ended at Shimoni, Kwale in Kenya. They spent over 3 years there as refugees. Guys in South Coast of Kenya know that pretty well. In nutshell, when death is beckoning, all things are sweet including the ever-blinding Pwani Si Kenya song!!!!

  • Kigulukire

    M R C is a vehicle that has already left and its unstoppable whatever the case come rain or sun

  • Kigulukire

    Go M R C Go

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