Cannabis eases sclerosis stiffness – study

Use of cannabis extract helps ease painful muscle stiffness among patients with multiple sclerosis (MS), according to a large trial published on Tuesday in the Journal of Neurology, Neurosurgery and Psychiatry.

The “Phase III” test — the final stage in a process to vet a new drug or medical process — took place among 22 centres in Britain.

Over 12 weeks, 144 patients were given daily tablets of tetrahydrocannabinol, which is the active ingredient in cannabis, and 135 were given a dummy pill, also called a placebo.

Doses were gradually escalated, from 2.5 milligrams to a maximum of 25 mg for two weeks, following top-up doses for the remaining two weeks.

At the end of the study, 29.4 percent of people in the cannabis group said they had experienced relief from muscle spasms, compared to 15.7 percent in the placebo group, according to an 11-point rating.

They also reported improvement in sleep quality. Side effects were nervous system disorders and gut problems, but none was severe.

MS, a disease that affects the brain and spinal cord, occurs when the immune system attacks the fatty myelin sheaths that insulate nerve cells.

Painful stiffness in the muscles occurs among up to 90 percent of patients at some time, often leading to poor sleep and impaired mobility.

The trial, led by John Peter Zajicek of Britain’s Clinical Neurology Research Group, says standardised doses of cannabis extract can be useful in easing pain and spasms in this disease.

Previous Phase III trials on cannabis and MS have thrown up conflicting results, partly because of the scale by which users report any change in their symptoms, the MUSEC researchers said.

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  1. Avatar tonydfixer October 10th, 2012 at 1:50 pm

    The old timer medicine wagon Docs had it right. Then the gov. got involved & hosed everybody over. Now big pharma. does not like the idea of legal medical cannabis for fear of loosing $$…..Tonydfixer….Seattle.

  2. Avatar Paulpot October 11th, 2012 at 4:10 pm

    A 2700 yr old grave in the Gobi desert had 2 pounds of psychoactive marijuana in it.
    The occupant of the grave was obviously a shaman and a healer.
    That’s how long at least that we have known that cannabis is a powerful healing herb.
    Prohibition is seriously equatable to The Inquisition.
    One of the parameters for finding a witch was someone who dealt in heathen forest crafts and herbal healing.
    Only prayer could heal you apparently. Certainly a better option than some of the modern pharmaceuticals but a severe regression on the knowledge of herb craft.
    And the fear and suspicion of the natural pharmacopoeia continues to this day to the great financial benefit of the companies that provide the alternatives we don’t need.
    Vote Yes on Marijuana reform ballots in Colorado, Oregon, Washington, Arkansas, Massachusetts.
    War is Over!


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