Assisted reproduction boosts risk of deformity: study


June 23, 2010 – Children born after assisted reproduction face a significantly higher chance of having major birth defects, according to a study released recently.

Parents contemplating assisted reproductive technology (ART) should be informed that such treatments carry increased risks, the researchers warned.

The study, the largest of its kind to date, reviewed all the ART births in 33 registered clinics in France from 2003 to 2007, more than 15,000 children in all.

“We found a major congenital malformation in 4.24 percent of the children,” said lead researcher Geraldine Viot, a clinical geneticist at the Port Royal maternity hospital in Paris.

The rate of such deformities for the general population is two to three percent.

“This higher rate was due in part to an excess of heart disease and malformations of the uro-genital system. This was much more common in boys,” she said in a statement.

Among minor malformations, there was a five-fold increase in cases of angioma, the formation of benign tumours on or near the surface of the skin. These occurred twice as frequently in girls than boys.

“We estimate that in France some 200,000 children have been born through ART. A malformation rate of this magnitude is a public health issue,” Viot said.

“It is important that all doctors — and also politicians — are informed about this,” she added.

Parents of children born with malformations were not on average older than other parents in the ART group, so age did not seem to be a factor.

It was unclear to what extent the malformations might be due to genetic variants passed along by the parents, or to the assisted reproduction techniques themselves, the researchers said.

“The origins of the malformation are probably multiple,” Viot said. “We need … to put much more effort into trying to understand which of the procedures involved is implicated in the problem.”

The most common techniques are in-vitro fertility (IVF) and a technique called intra cytoplasmic sperm injection (ICSI).

Women can also receive hormone therapy to restore or stimulate ovulation.

IVF consists of fertilising a woman’s eggs outside the body and then placing them inside the womb, whereas in ICSI a single sperm is injected directly into an egg.

Earlier studies have shown that the most common cause of IVF failure is an abnormal number of chromosomes in the egg.

These so-called “gene imprinting” disorders could also play a role in the higher rate of malformations, Viot suggested.

“At a time when infertility is increasing and more and more couples need to use ART to conceive, it is vitally important that we find out as much as we can about what is causing malformations in these children,” Viot said.

A Danish study released in February showed that women who undergo IVF treatment are four times more likely to have a stillbirth compared with those who conceive spontaneously or with a different fertility technique.

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  1. Avatar JOM May 9th, 2012 at 5:35 pm

    so what are you thinking?

  2. Avatar scanfish May 10th, 2012 at 7:26 am

    Welcome to the real world. What you see is not necessarily what you get, whether with reference to Raila or the ICC.
    We have been telling you all this time that Raila is not who he and his supporters claim to be, the current NHIF scam now dominating discussion just being the latest scandal that seriously questions Raila’s integrity, and it is a pity it has taken you 4 years to realise that.

    In the same vein, we have been telling you the ICC is more of a western political tool and kangaroo court than an impartial world court that is blind to prejudice against anyone, more so against Africans. Well, it seems you have had an epiphany and now know better i.e the court can indeed be manipulated to achieve goals that conform with hegemonic and imperialistic western geo-political and economic interests, such as installing a willing and over-enthusiastically malleable puppet in Raila Odinga inside State House.

    Hope you will exercise better judgement next time, a more chastened and enlightened man.

    1. Avatar Tiptip May 10th, 2012 at 12:37 pm

      Your view on ICC court boggles mind.This reminds me of the cult like support dictators of yester years within Africa used to enjoy.When Idi Amin used to reign terror on Ugandan citizens ,kenyan and african leadership never bothered and silent collusion was evidenced.The same happened with Bukasa in the western african country.If there were ICC court then, lives could have been saved.The same applies to your case. Since you have an ethnic agenda to push, as a supporter of the accused, you don’t care about the victims.Your local dialect is more important than life of the PEV.

  3. Avatar jo-c May 10th, 2012 at 1:19 pm

    nice and truthful article…………..continue writing such factual, flowing, and well researched articles.

  4. Avatar ndobolo May 10th, 2012 at 6:10 pm

     I think Raila’s party has engineered theft of public money in NHIF for use in their election campaign,their credibility is now in big doubt.

  5. Avatar Pratt May 11th, 2012 at 9:20 am

    Am amazed by your twisted and almost pretentious facts. Either you have failed to read your favorite idol correctly, or simply dont know whats agenuine good leader. First, a genuine leader must have the welfare of the people at heart. That cant be said of Raila at all. Remember only the other day, he spent mind-boggling KShs. 601,000/= for a hotel room. That was done while his compatriots were barely scavenging to live. And not only that, severally, Raila has taken off once the riot police checks in, leaving his supporters to face the music. A genuine leader would even opt to be arrested for the safety of  his poor supporters. After all, he is the once who assemled them against the police wishes, if not the law. A true genuine leader must have true loyalty to his country. He must be willing to sacrifice and even die for his country. Surely, same cant be said of your “genuine” idol. He doesnt help the needy or even contibute funds for projects/harambee. He is a mean character who feels or has created the impression that Kenyans owe him. He has repeatedly visited violence on Kenyans in no less than two occasions. Both in 1982 and 2007/8, the genesis of mayhem, destruction and death was his art at its finest! His words and actions have ended up creating problems for the country at her borders. A genuine leader pursues the truth and truth alone. Your purported genuine leader has no room for truth at all. He relies on falsehoods and extremely toxic malicious propaganda. Am sure you have read the stuff meant to question Hon. Mudavadi credentials. Instead of going by facts and facts alone, only Raila’s known deeds are twisted to mean Mudavadi’s! To suggest that those who have left Raila were behind his failures is to insult our intelligence to the extreme. Raila himself is on record declaring them his “students!” And here you are telling us the opposite! Whats the matter pal? Do you know even Raila’s famous declaration “Kibaki Tosha” was also a monumental deception? Hon. Simon Nyachae was then the favorite compromise candidate. But that in itself, threatened your “genuine leader’s” political career. Thus, the Kibaki tosha thing. Nyachae comes from Nyanza and Raila wont allow another alternative power in the area. Its so simple to discern pal! No good faith and no loyalty at all. Talk of killing two birds with one stone!

  6. Avatar Demulato May 11th, 2012 at 11:39 am

    Noone got Kosgey or Ali from Hague, their defence did, get right on this. I also don’t know what you mean by Genuine. Its subject to subjectivity, I’ve not yet seen any objective points to your changed view, I’ve just seen your initial and final state, the process conspicuously lacks.

  7. Avatar Juma Robert May 14th, 2012 at 6:56 pm

    This fellow down here called Pratt stinks of bitterness! Claiming that Raila has not sacrificed enough for his supporters sounds like the fellow was brought up in some isolated island! No current politician, including President Kibaki has fought for a just Kenya like Raila. The fellow has been arrested, molested and locked up by the powers that be! Get your facts right before bickering, the rest of the story is too long to be read!

    1. Avatar Kwessi Pratt May 17th, 2012 at 4:59 pm

      Thats rich pal! I for one never dwell on generalities, I offer facts and facts alone. If thats what you are calling bitterness, then I have no idea whats bitterness. You need to offer specificity on those sacrifices by your idol pal. Raila was arrested in 1982 for his involvement in a failed tribal coup. Apparently, he had financed junior Airforce luo officers to stage a coup. That was clearly expounded on during his treason trial. Treason is a pure very serious criminal offence, but certainly not a “fight or sacrifice for us!” He was never arrested for any other issue at all. His treason trial was superseded by detention, which was very lawful then. As you might know, president had legal powers to detain inciters or troublesome fellows like Raila. Raila inspite of endless senseless songs of reform, has never mellowed with time. Its unfortune fictitious feats have been created out of pure criminal case! We have been repeatedly told that he “fought” for multipartyism, but thats also another fake feat. When we were fighting for multiparty, the creature was still fighting off treason charges or was in detention. And in any case, his late father was in the frontline. Politically, father and son cant stand toe to toe. The sons are always unknown. Therefore, unless Raila wants to pretend he was the father,  there is no way he could have “fought for us” even if he wanted! There was no space for him at all. Thats actually why  he started claiming, after his father’s death, that it was a “biological mistake” for him to have been born son of Jaramong! Even that act of talking of biological mistakes explains his very early opportunistic tendencies! Needless to say, attempting to disown your father, albiet mischieviously, is a curse pal. I guess thats why the fellow has had a history of blood letting. And dont ever forget, all indications are that the fellow is on a very steep descend! 

  8. Avatar Curious May 23rd, 2012 at 8:16 am

    I don’t know how old you are but I find your arguments extremely naive.

    If you read your own last three paragraphs about what RO has gone offering Ruto, then clearly it does not rhyme with the subject of your article. He is either lying to Ruto or he did actually spring an ICC suspect and put others in, whichever the case that is not my idea of a genuine person. 

    Clearly this is a man, in your own words, who would “sacrifice anything including Kenyas own existence” to get what he wants. There is the small matter of 1982 , I need not say more about it. We all saw on TV, national and international, what happened in December 2007/January 2008 ACROSS the country. The key word here is ACROSS THE COUNTRY. I am also sure I am not the only one that heard him boast, on TV again, how Kenya will become ungovernable like Ivory Coast.

    I suppose you may have got a personal apology from the man and the ODM party considering that he’s your new found pal, but all I have heard and seen is loud silence and smug satisfaction. 

    While still on the subject of absurd justifications, you clearly never heard Raila’s BBC Hardtalk interview in mid Jan 2008 justifying the events at Kiambaa church. I would advice you to search the BBC website for the clip before you go shouting from the rooftops.

  9. Avatar MS April 17th, 2013 at 6:38 pm

    Raila is a great, genuine and charismatic leader but your argument is, if anything, choreographed and lacks depth. He may have tried not to make the same mistakes he made in 2007 but you skillfully evaded mentioning the bigger miss-steps he made this time round. Fact remains that this was his election to lose and he sadly lost.

  10. Avatar odhies June 12th, 2014 at 2:11 pm

    raila is a backer whose hypocrisy in not definite to Kenyan he is after revenge mission he making every dry grass green to get to the seat and do what is called dictatorship. look president Museveni hates the whites with concrete reasons on their conspiracy to Africa he hates too raila what does that mean? raila aint a good man believe me wait an u will c. i voted for him but am regreting.he is using threats to force the government to dialogue with him for what benefit is he after


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