The exploration well reached a total depth of 3,000 metres without finding commercial hydrocarbons.
The Emesek-1 well was drilled by the PR Marriott 46 rig and will now be plugged and abandoned.
The rig will move to the South Lokichar basin to drill the Etom-2 well.
Tullow has a 50 percent stake and partner Africa Oil Corporation the remaining 50 percent.
“The Emesek-1 well was the first well to be drilled in the North Lokichar basin. While this wildcat well did not find commercial hydrocarbons, it provides valuable data as we assess the wider prospectivity of this basin,” Tullow Oil Plc Exploration Director Angus Mccoss says.
The Etom-2 well is expected to spud in late November.