Manchester United, who were just pipped to the title on the final day of the 2011/12 season, are away to Everton before Fulham visit Old Trafford the following weekend.
Arsenal, third last term, start at home to Sunderland before travelling to Stoke and Liverpool.
The opening day of the season sees two Europa League rivals go head-to-head when Newcastle welcome Tottenham Hotspur, currently without a manager following the departure of Harry Redknapp, to St James’ Park.
European champions Chelsea, with Roberto di Matteo now their full-time as opposed to caretaker manager, begin their quest for the Premier League title away to Wigan. Newcastle will be the first league visitors to Stamford Bridge.
Brendan Rodgers’ first Premier League match as Liverpool manager will be at West Bromwich Albion, now managed by former Chelsea and Liverpool assistant Steve Clarke after the Baggies lost Roy Hodgson to England.
Swansea, the team Rodgers left, will have the first league game under new manager Michael Laudrup at Queens Park Rangers.
West Ham’s return to the Premier League starts at home to Aston Villa, now managed by former Norwich boss Paul Lambert.
Fellow newcomers Reading will also have home advantage in their first top flight game for four years when Stoke arrive at the Madejski Stadium.
Meanwhile Fulham and Norwich meet at Craven Cottage in Chris Hughton’s first competitive game since replacing Lambert as Canaries boss.
Meanwhile, Cash-strapped Glasgow giants Rangers were omitted from the Scottish Premier League (SPL) fixture list annnounced Monday, with their place taken by a yet-to-be decided ‘Club 12’.
Rangers were docked 10 points for entering administration last season, a decision that helped Celtic win the SPL title.
League officials have still to decide if Rangers will play in Scottish football’s top-flight next season after a consortium led by English businessman Charles Green took over the club by creating a new company to run its business.
Opening day – Saturday 18 August
Arsenal v Sunderland
Everton v Manchester United
Fulham v Norwich City
Manchester City v Southampton
Newcastle United v Tottenham Hotspur
Queens Park Rangers v Swansea City
Reading v Stoke City
West Bromwich Albion v Liverpool
West Ham United v Aston Villa
Wigan Athletic v Chelsea
Saturday 25 August
Aston Villa v Everton
Chelsea v Newcastle
Liverpool v Manchester City
Manchester United v Fulham
Norwich City v Queens Park Rangers
Southampton v Wigan Athletic
Stoke City v Arsenal
Sunderland v Reading
Swansea City v West Ham United
Tottenham Hotspur v West Bromwich Albion