The operation, which did not involve US troops on the ground, took place on Thursday on a road south of Mogadishu and focused on “a high-value target,” spokesman Colonel Steven Warren told reporters.
“This operation was conducted against the al-Shabaab network,” Warren said.
“We are currently assessing the results of this operation and will provide additional information as and when appropriate.”
An armed drone carried out the strike, a US defence official, who spoke on condition of anonymity, told AFP.
The Pentagon declined to comment on reports, citing Kenyan officials, that the strike targeted a Shabaab figure who orchestrated the 2013 attack on the Westgate mall in Nairobi, which left 67 people dead.